top of page


Dalal, P. J., Sullivan, D. P., Weber, E. W., Sacks, D. B., Gunzer, M., Grumbach, I. M., Brown, J. H., Muller, W. A., Spatiotemporal Restriction of Calcium Signaling in Endothelial Cells during Leukocyte Transmigration. Journal of Experimental Medicine, (2021) 218 (1): e20192378.


Ninh, V. K., Brown, J. H., The Contribution of the Cardiomyocyte to Tissue Inflammation inCardiomyopathies, Current Opinion in Physiology, 19: 129-134, 2021.

Calcagno, D., Zhang, C., Toomu, A., Huang, K., Ninh, V., Miyamoto, S., Aguirre, A., Fu, Z., Brown, J. H., and King, K., SiglecF(HI) marks late stage neutrophils of the infarcted heart- a single cell transcriptomic analysis of neutrophil diversification. JAHA, 2021, 10:e019019.

Pavez-Giani MG, Sánchez-Aguilera PI, Bomer N, Miyamoto S, Booij HG, Giraldo P, Oberdorf-Maass SU, Nijholt KT, Yurista SR, Milting H, van der Meer P, Boer RA, Heller Brown J, Sillje HWH, Westenbrink BD. ATPase Inhibitory Factor-1 Disrupts Mitochondrial Ca2+ Handling and Promotes Pathological Cardiac Hypertrophy through CaMKIIδ. Int J Mol Sci. 2021 Apr 23;22(9):4427. doi: 10.3390/ijms22094427



Lu, S., Liao, Z., Lu, X., Katschinski, D.M., Mercola, M., Chen, J., Brown, J.H., Molkentin, J. D., Bossuyt, J., Bers, D. M., Hyperglycemia Acutely Increases Cytosolic Reactive Oxygen Species via Olinked GlcNAcylation and CaMKII Activation in Mouse Ventricular Myocytes. Circ Res., 2020 May; 126(10):e80-e96


Zhang, J.Z., Nguyen, A.H., Miyamoto, S., Brown, J.H., McCulloch, A.D., Zhang, J., Histamine-induced biphasic activation of RhoA allows for persistent RhoA signaling. PloS Biol. 2020 Sep, 18(9): e3000866

Ljubojevic-Holzer, S., Herren, A. W., Morotti, S., Holzer, M., Sacherer, M., Wood, B. M., Wallner, M., Sossalla, S., Ivanov, M., Lewinski, D. V., Pieske, B., Brown, J. H., Sedej, S., Bossuyt, J., Bers, D. M., CaMKIIδC Drives Early Adaptive Ca2+ Change and Late Eccentric Cardiac Hypertrophy. Circ Res., 2020 Oct; 127:1159–1178



Byun, J., Del Re, D. P., Zhai, P., Ikeda, S., Shirakabe, A., Mizushima, W., Miyamoto, S., Brown, J. H., Sadoshima, J. Yes-associated protein (YAP) mediates adaptive cardiac hypertrophy in response to pressure overload. J Biol Chem 294:3603-3617, 2019.

Suetomi T, Miyamoto S, Brown J.H., Inflammation in non-ischemic heart disease: initiation by cardiomyocyte CaMKII and NLRP3 inflammasome signaling, Am J Physiol Heart Circ Physiol. 2019 Nov 1;317(5):H877-H890.



Pollack A. J., Liu C., Gudler A., Mayfield J. E., Dalton N. D., Gu Y., Chen J., Brown J. H., Hogan, P. G., Wiley, S. E., Peterson, K. L., Dixon, J. E. A secretory pathway kinase regulates sarcoplasmic reticulum Ca homeostasis and protects against heart failure. Elife. 2018;7: e41378 doi:10.7554/eLife.41378. [Epub ahead of print].


Suetomi T., Willeford A.W., Brand C. S., Cho Y., Ross R. S., Miyamoto S., Brown J. H. Inflammation and NLRP3 inflammasome activation initiated in response to pressure overload by CaMKIIδ signaling in cardiomyocytes are essential for adverse cardiac remodeling. Circulation.  2018;138: 2530-2544


Brand C. S., Tan V. P., Brown J. H.,Miyamoto S. RhoA regulates Drp1 mediated mitochondrial fission through ROCK to protect cardiomyocytes. Cell Signal. 2018 Jun 25; 50:48-57


Willeford A., Suetomi T., Nickle A., Hoffman HM, Miyamoto S., Brown J. H. Cardiomyocyte CaMKIIδ-mediated inflammatory gene expression and inflammasome activation in cardiomyocytes initiate  inflammation and induce fibrosis. JCI Insight. 2018. Jun 21;3 (12): 


Yu O.M., Benitez J.A., Plouffe S. W., Ryback D., Klein A., Smith J., Greenbaum J., Delatte B., Rao A., Guan K.L., Furnari F.B., Chaim O.M., Miyamoto S., Brown, J.H. YAP and MRTF-A transcriptional co-activators of RhoA-mediated gene expression are critical for glioblastoma tumorigenicity. Oncogene. 2018. Jun 11. doi: 10.1038/s41388-018-0301-5. [Epub ahead of print]

F1000 Prime Recommended

Crotty Alexander L.E., Drummond C.A., Hepokoski M., Mathew D.P., Moshensky A., Willeford A., Das S., Singh P., Yong Z., Lee J.H., Vega K., Du A., Shin J., Javier C., Tian J., Brown J. H., Breen E.C. Chronic Inhalation of E-Cigarette Vapor Containing Nicotine Disrupts Airway Barrier Function and Induces Systemic Inflammation and Multi-Organ Fibrosis in Mice.  Am J Physiol Regul Integr Comp Physiol.2018 Jun 1;314(6):R834-R847.






Burel, S., Coyan, F.C., Lorenzini, M., Meyer, M.R., Lichti, C.F., Brown, J.H.,Loussouam G, Charpentier, F., Nerbonne, J.M., Townsend, R., Maier, L.S., Marionneau, C. C-Terminal Phosphorylation of Nav1.5 Impairs FGF13-Dependent Regulation of Channel Inactivation. J Biol Chem. 2017 Oct 20; 292(42):17431-17448.  


Castalidi A., Dodia R.M., Orogo A.M., Zambrano C.M., Najor R.H., Gustafsson A.B., Brown J.H., Purcell N.H. Decline in cellular function of aged mouse c-kit+cardiac progenitor cells. J Physiol. 2017 Oct 1;595(19):6249-6262. Doi: 10.1113/JP274774. Epub 2017/Aug 18.


Dusaban, S.S., Rosen, H., Chun, J., Purcell, N.H., Brown, J.H. Sphingosine 1-phosphate receptor 3 and RhoA signaling mediate inflammatory gene expression in astrocytes. J. Neuroinflammation. 2017 Jun 2; 14(1):111.


Dewenter M., Neef S., Vettel C., Lammle S., Beushausen C., Zelarayan L.C., Katz S., von der Lieth A., Meyer-Roxlau S., Weber S., Wieland T., Sossalla S., Backs J., Brown J.H., Maier L.S., El-Armouche A. Calcium/Calmodulin-Dependent Protein Kinase II Activity Persists During Chronic β-Adrenoceptor Blockade in Experimental and Human Heart Failure. Circ Heart Fail, 2017 May; 10(5):e003840. Doi: 10.1161/CIRCHEARTFAILURE.117.003840. PMID2848732. 


Yung, B., Brand, C., Xiang, Y., Purcell, N.H., Gray, C.B.B., Rosen, H., Chun, J., Miyamoto, S., Brown J.H., Selective coupling of the S1P3 receptor subtype to S1P-mediated RhoA activation and cardioprotection, J Mol Cell Cardiol, 103:1-10. 2017.


Gray, C.B.B., Suetomi, T., Xiang, S., Mishra, S., Blackwood, E.A., Glembotski, C., Miyamoto, S., Westenbrink, B.D., Brown, J.H. CaMKIIdsubtypes differently regulate infarct formation following ex vivomyocardial ischemia/reperfusion through NF-kB and TNF-a. J Mol Cell Cardiol. 2017 Feb; 103: 48-55. 






Castaldi A., Chesini. G., Taylor, A., Purcell, N., Brown J.H., Sphingosine 1-Phosphate elicits RhoA-dependent CPC proliferation and MRTF-A mediated gene induction. Cell Signal, 28:871-879, 2016.


Hoydal, M, Stolen, T.O., Kettlewell, S., Maiers, L.S., Brown, J.H., Sowa, T., Catalucci, D., Condorelli, G., Kemi, O.J., Smith, G.L., Wisloff, U., Exercise Training reverses myocardial dysfunction induced by CaMKIIδc overexpression by restoring Ca2+-homeostasis. Journal of Applied Physiology; 121: 212-220, 2016.


Miyamoto S., Brown J.H., Drp1 and Mitochondrial Autophagy Lend a Helping Hand in Adaptation to Pressure Overload

Circulation, 133(13):1225-7, 2016.


Panama, B.K., Korogyi A., Aschar-Sobbi, R., Oh, Y., Gray, C.B.B., Gang, H., Brown, J.H., Kirshenbaum, L.A., Backx, H., Reductions in the cardiac transient outward K+ current Ito caused by chronic β-adrenergic receptor stimulation are partly rescued by inhibition of nuclear factor kappaB, J. Biol. Chem. 291(8):4156-65, 2016.


Sanna M.G., Vincent K.P., Repetto E., Nguyen N., Brown S.J, Abgaryan L., Riley S.W, Leaf N.B, Cahalan S.M, Kiosses W.B, Kohno K., Brown J.H., McCulloch A, Rosen H., and Gonzalez-Cabrera P., Bitopic S1P3 Antagonist Rescue from Complete Heart Block: Pharmacological and Genetic Evidence for Direct S1P3 Regulation of Mouse Cardiac Conduction, Mol Pharmacol.;89(1):176-86, 2016.


Yu, OM., Miyamoto, S., Brown, J.H., MRTF-A and YAP exert dual control in GPCR and RhoA-mediated transcriptional regulation and cell proliferation, Mol Cell Biol.; 36(1):39-49, 2016.  F1000 Prime Recommended





Dusaban, S, Kunkel, M.T., Smrcka, A.V., Brown J.H., Thrombin Promotes Sustained Signaling and Inflammatory Gene Expression through the CDC25 and Ras Associating Domains of Phospholipase C-epsilon, J Biol Chem.; 290(44):26776-83, 2015.


Grimm M., Ling H., Pereira L., Erickson J.R., Gray C.B.B., cull-cand A., Sarma S., Respress J. L., Wehrens X.T.,Bers D.M, Brown J.H. CaMKIIδ mediates β-adrenergic effects on RyR2 phosphorylation and SR Ca2+ leak and the pathophysiological response to chronic β-adrenergic stimulation, J Mol Cell Cardiol.;85:282-291, 2015.


Brown J.H, Catterrall W., Conn P.J., Cull-Candy S.G., Dingledine R., Kendall T., Insel P.A., Milligan G., Traynelis S., The First 50 Years of Molecular Pharmacology, Molecular Pharmacology, 115.099564, 2015.


Yu O.M and Brown, J.H., GPCR and RhoA-stimulated transcriptional responses: links to inflammation, differentiation and cell proliferation, Mol Pharmacol.; 88(1):171-80, 2015.


Westenbrink D.B., Ling H., Miyamoto S., Divakaruni A., Gray C.B.B., Zambon A., Dalton N., Peterson K., Gu Y., Matkovich S., Murphy A., Dorn G.W., Brown J.H., Mitochondrial reprogramming induced by CaMKIIδ mediates hypertrophy decompensation. Circ Res.; 116(5):e28-39, 2015.


Dusaban S.S., Brown J.H., PLCε mediated sustained signaling pathways, Advances in Biological Regulation, Jan;57C:17-23, 2015.





Edwards A.G., Hake J. E., Patel S., Grandi E., Li P., Miyamoto S., Omens J. H.,Brown J.H., Bers D. M., McCulloch A.D, Nonequilibrium reactivation of Na+ current drives early after depolarizations in Mouse Ventricle, Circ Arrhythm Electrophysiol.;7(6):1205-13, 2014.


Suarez J, Wang H, Scott BT, Ling H, Makino A, Swanson E, Brown JH, Suarez JA, Feinstein S, Diaz-Juarez J, Dillmann WH. In vivo selective expression of thyroid hormone receptor a1 in endothelial cells attenuates myocardial injury in experimental myocardial infarction in mice. Am J Physiol Regul Integr Comp Physiol; 307(3):R340-6, 2014.


Zhao X., Ding E.Y., Yu O.M., Xiang S.Y., Tan-Sah V.P., Yung B.S., Hedgpeth J., Neubig R.R., Lau L.F., Brown J.H., Miyamoto S. Induction of the matricellular protein CCN1 through RhoA and MRTF-A contributes to ischemic cardioprotection. J Mol Cell Cardiol.;75:152-61, 2014.


Di Carlo M, Said M., Ling H., Valverde C, DeGiusti V., Sommese L., Palomeque J., Aiello A.,. Skapura D, Rinaldi G., Respress J., Brown J.H., Wehrens X.H.T., Salas M, Mattiazzi, A., CaMKII-dependent phosphorylation of cardiac ryanodine receptors regulates cell death in cardiac ischemia/reperfusion injury. J Mol Cell Cardiol, 74:274-83. 2014.


Sayyah J, Bartakova A, Nogal N, Quilliam LA, Stupack DG, Brown J.H.,Rap1A mediates thrombin stimulated, integrin-dependent glioblastoma cell proliferation and tumor growth. J Biol Chem. 20;289(25):17689-98 2014


Gray C, Brown J.H., CaMKII delta subtypes: Localization and Function, Frontiers in Pharmacology, 11;5:15, 2014.


Benincá C., Planagumà J., Shuck A. F., Acín-Perez R., Muñoz J. P., Almeida M. M., Brown, J.H.,Murphy A. N., Zorzano A., Enríquez J. A., Aragay A. M., A new non-canonical pathway for Gq protein in regulating mitochondrial dynamics and bioenergetics, (5):1135-46, 2014.


Zhang D.M., Chai Y., Erickson J., Brown J.H.,Bers D., Lin Y.F. Modulation of Sarcolemmal ATP-Sensitive Potassium Channels by Nitric Oxide via sGC/PKG/ROS/ERK1/2/CaMKII Signaling in Ventricular Cardiomyocytes.J Physiol, 1;592(Pt 5):971-90. 2014.





Xiang S.Y., Dusaban S.S., and Brown J.H. Lysophospholipid receptor activation of RhoA and lipid signaling pathways. BBA- Molecular and Cell Biology of Lipids; 1831(1):213-22, 2013.


Chen B., Van Winkle J.A., Lyden P.D., Brown, J.H., and Purcell, N.H. PHLPP1 Gene Deletion Protects the Brain from Ischemic Injury. J. Cereb. BloodFlow & Metab., 33(2):196-204, 2013.


Ling H., Gray C.B.B., Zambon A.C., Grimm M., Gu Y., Dalton N., Purcell N.H., Peterson K., Brown J.H. CaMKIIδ mediates myocardial ischemia/reperfusion injury through NFkB. Circ. Res. 112(6):935-44, 2013. 


Dusaban S.S., Purcell N.H., Rockenstein E., Masliah E., Cho M.K., Smrcka A.V., and Brown J.H. Phospholipase C-epsilon links G-protein coupled receptor activation to inflammatory astrocytic responses. Proc Natl Acad Sci. 110(9) 3609-14, 2013.


Westernbrink D.B., Edwards A, McCulloch A.D, Brown J.H., The Promise of CaMKII inhibition for heart disease: preventing heart failure, Expert Opinion on Therapeutic Targets, Vol. 17, No. 8 , P889-903, 2013.






Mo J.S., Yu F., Gong R., Brown J.H., and Guan K.L.  Regulation of the Hippo-YAP pathway by the protease activated receptor PAR1. Genes and Development, 26(19):2138-43, 2012.


Ortiz-Sanchez, J.M., Nichols, S.E., Sayyah, J., Brown, J.H., McCammon, J.A. Grant, B.J.  Identification of potential small molecule binding pockets on Rho family GTPases. PLoS One, 7(7):e40809, 2012.


Scimia M.C., Hurtado C., Ray S., Wei K., Wang J., Woods C.E., Purcell N.H., Catalucci D., Akasaka T., Bueno O.F., Vlasuk G.P., Kaliman P., Bodmer R., Smith L.H., Ashley E., Brown J.H., Mercola M., and Ruiz-Lozano P. APJ acts as dual receptor in cardiac hypertrophy. Nature, 16;488 (7411):394-8, 2012.


Miyamoto S., Xiang S.Y., Purcell N. and Brown J.H. Mechanisms and models for elucidating the cardiac effects of  Sphingosine 1 phosphate (S1P). In: Lysophospholipid Receptors: Signaling and Biochemistry John Wiley & Sons, Inc. 2012.


Guo T., Zhang T., Ginsburg K.S., Mishra S., Brown J.H. and Bers D.M. CaMKIIδC slows [Ca2+]i decline in Cardiac Myocytes by promoting Ca2+ sparks. Biophysical J.102(11):2461-70, 2012.


Smrcka A.V., Brown J.H., Holz G.G. Role of phospholipase Cε in physiological phosphoinositide signaling networks. Cell Signaling. 24(6): 1333-43, 2012.


Brown J.H. and Laiken N.  Acetylcholine and Muscarinic Receptors.  In: Primer on the Autonomic Nervous System, Third Addition, Elsevier, 75-77, 2012.





Grant B.J., Lukman S., Hocker H.J., Sayyah J., Brown J.H., McCammon J.A., and Gorfe A.A. Novel allosteric sites on Ras for lead generation. PLoS One, (10): e25711, 2011. 


Mishra S., Gray C., Miyamoto S., Bers D.M. and Brown J.H. Location matters: clarifying the concept of nuclear and cytosolic CaMKII subtypes. Circ Res, 109 (12):1354-62, 2011. 


Anderson M.E., Brown J.H. and Bers D.M. CaMKII in myocardial hypertrophy and heart failure. J. Mol Cell Cardiol, 51:468-473, 2011. 


Grimm M., Ling H., Brown J.H. Crossing signals: relationships between β adrenergic stimulation and CaMKII activation. 

Heart Rhythm, 8: 1296-1298, 2011. 


Xiang S. Y., Vanhoutte D., Del Re D. P., Purcell N.H., Ling H., Banerjee I., Bossuyt J., Lang R.A., Zheng Y., Matkovich S.J., Miyamoto S., Molkentin J.D., Dorn II G.W. 2nd, and Brown J.H. RhoA protects the mouse heart against 

ischemia/reperfusion injury. J. Clin Invest, 121: 3269-3276, 2011.


Sadayappan S., Gulick J., Osinska H., Barefield D., Cuello F., Avkiran M., Lasko V.M., Lorenz J.N., Maillet M., Martin J.L., Brown J.H., Bers D.M., Molkentin J.D., James J., and Robbin J. A critical function for Ser-282 in cardiac Myosin binding protein-C phosphorylation and cardiac function. Circ Res, 109: 141-150, 2011. 


Huke S., DeSantiago J., Kaetzel M.A., Mishra S., Brown J.H., Dedman J.R., and Bers D.M.  SR-targeted CaMKII inhibition improves SR Ca handling, but accelerates cardiac remodeling in mice overexpressing CaMKIIδC.  J. Mol Cell Cardiol, 50:230-238, 2011. 


Dybkova N., Sedej S., Napolitano C., Neef S., Rokita A.G., Hunlich M, Brown J.H., Kockskamper J., Priori S.G., Pieske B and Maier LS.  Overexpression of CaMKIIδc in RyR2 (R4496C+/-) knock-in mice leads to altered intracellular Ca2+ handling and increased mortality. J Am College Cardio, 57:469-479, 2011.


Brown J.H. and Laiken, N.  Muscarinic receptor agonists and antagonists.  In: Goodman and Gilman’s, The Pharmacological Basis of Therapeutics, Twelfth Addition, McGraw-Hill Press, 219-238, 2011.

bottom of page